化工社化工社 化学情報印刷レポート · 研究参考用
p-Fluorophenethylamine → 4-chloro-N-[2-(4-fluorophenyl)ethyl]-6-methoxy-1,3,5-triazin-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Fluorophenethylamine | HCID 4653 | — |
| 反応物 | 2,4-Dichloro-6-methoxy-3,5-triazine | HCID 19267 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-chloro-N-[2-(4-fluorophenyl)ethyl]-6-methoxy-1,3,5-triazin-2-amine | HCID 62859305 | — |
反応手順
A solution of 10 g of 2,4-dichloro-6-methoxy-1,3,5-triazine in 200 ml of acetonitrile is cooled on an ice bath, 8.73 ml of DIPEA and then 6.56 ml of 2-(4-fluorophenyl)ethanamine are added and the mixture is stirred. The precipitate formed is drained by suction, washed with EtOAc and dried. 13.7 g of the expected compound are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09115121B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-1124e434b6e64bda8202f8de33eba748 |
| 出典メモ | uspto-grants-2015_08 |