Sodium Bromide → 3-Bromo-1-(3-bromophenyl)butan-2-one

HRID 517551ノート

反応式

HRID 517551 の反応式
[Na+].[Br-:2].[Br:3][C:4]1[CH:5]=[C:6]([CH2:10][C:11](=[O:15])[CH:12](Cl)[CH3:13])[CH:7]=[CH:8][CH:9]=1>CC(C)=O.CCCCCC>[Br:2][CH:12]([CH3:13])[C:11](=[O:15])[CH2:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([Br:3])[CH:5]=1

参加物

5

反応物 2

HCID 253881Sodium BromideHCID 867114911-(3-Bromophenyl)-3-chlorobutan-2-one

生成物 1

HCID 867114923-Bromo-1-(3-bromophenyl)butan-2-one

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 8058Hexane溶媒

反応条件

温度
70 °C

実験手順

A mixture of NaBr (197 mg, 1.9 mmol) and 1-(3-bromophenyl)-3-chlorobutan-2-one (100 mg, 0.38 mmol) in acetone (2 ml) was stirred at 70° C. for 3 h. The mixture was diluted with hexane and filtered to remove the solid. The solvent was removed under reduced pressure and the residue was used for the next step without further purification. MS (ES+) C10H10Br2O requires: 303, 305 found: 304, 306 [M+H]+(1:1).

後処理

  1. filtrationfiltered
  2. customto remove the solid
  3. customThe solvent was removed under reduced pressure
  4. customthe residue was used for the next step without further purification

出典と根拠

ORDレコード
ord-8d51c3e1bfe7421f991cd64aee8c6583
出典データセット
uspto-grants-2015_08
特許番号
US09115120B2

反応ノート

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