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4-Methylbenzaldehyde → 3-(2-Aminoethyl)-5-[(4-methylphenyl)methylidene]-1,3-thiazolidine-2,4-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methylbenzaldehyde | HCID 7725 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 3-(2-Aminoethyl)-5-(phenylmethylidene)-1,3-thiazolidine-2,4-dione | HCID 1551244 | — |
| 反応物 | 3-(2-(Tritylamino)ethyl)thiazolidine-2,4-dione | HCID 71697168 | — |
| 生成物 | 3-(2-Aminoethyl)-5-[(4-methylphenyl)methylidene]-1,3-thiazolidine-2,4-dione | HCID 2432691 | — |
反応手順
The title compound 30d was prepared from 4-methylbenzaldehyde (73 μL, 0.62 mmol), compound 29 (250 mg, 0.62 mmol) and piperidine (7.0 μL, 0.062 mmol) in a manner similar to that described for 30a in 36.0% (83 mg) yield as a cream solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09115122B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-2f931743f34044309890919c7d598b28 |
| 出典メモ | uspto-grants-2015_08 |