Formaldehyde → (cis)-4-{[1-(4-Chlorophenyl)-1H-tetrazol-5-yl]methyl}-2,6-dimethylmorpholine

関与物質

役割	名称	HCID	仕込み量
反応物	Formaldehyde	HCID 712	—
反応物	4-Chlorophenyl isocyanide	HCID 74670	—
反応物	Azidotrimethylsilane	HCID 78378	—
反応物	2,6-Dimethylmorpholine, cis-	HCID 641500	—
溶媒	Methanol	HCID 887	—
生成物	(cis)-4-{[1-(4-Chlorophenyl)-1H-tetrazol-5-yl]methyl}-2,6-dimethylmorpholine	HCID 86691886	—

反応手順

To a solution of (cis)-2,6-dimethylmorpholine (104 mg, 0.900 mmol, Alfa Aesar, Ward Hill, USA) in methanol (3 mL) was added formaldehyde (37% aqueous) (0.067 mL, 0.900 mmol). The reaction mixture was shaken at room temperature for 2 hours. To the reaction mixture was added 4-chlorophenyl isocyanide (138 mg, 1 mmol) and trimethylsilylazide (0.133 mL, 1.00 mmol). The reaction mixture was shaken at room temperature for a further 18 hours.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09115132B2
出典データセット	uspto-grants-2015_08
ORD ID	ord-5ec900c6c37741e98fb497b74b02dcc7
出典メモ	uspto-grants-2015_08