Triethylamine → (S)-(1-(pyridin-2-yl)pyrrolidin-3-yl)methanol

HRID 517950

反応式

[NH:1]1[CH2:5][CH2:4][C@H:3]([CH2:6][OH:7])[CH2:2]1.F[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1.C(N(CC)CC)C>CO>[N:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[N:1]1[CH2:5][CH2:4][C@H:3]([CH2:6][OH:7])[CH2:2]1

参加物

反応条件

温度: 150 °C

実験手順

(S)-Pyrrolidin-3-ylmethanol (9.89 mmol, 1 g), 2-fluoropyridine (29.7 mmol, 2.88 g) and triethylamine (49.4 mmol, 6.89 ml, 5.00 g) were dissolved in MeOH (2.5 ml) and heated to 150° C. for 1 hour in the microwave. The resulting residue was purified by silica chromatography, eluting with DCM—5% MeOH/DCM to afford (S)-(1-(pyridin-2-yl)pyrrolidin-3-yl)methanol (1.03 g).

後処理

customThe resulting residue was purified by silica chromatography
washeluting with DCM—5% MeOH/DCM

出典と根拠

ORDレコード: ord-e80e2012ce1c4ce8aaec60440275cec8
出典データセット: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09115126B2

反応式

参加物

反応物 3

生成物 1

試薬・触媒・溶媒 1

反応条件

実験手順

後処理

出典と根拠

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