Ethyl 2-azido-3-(5-methylthiophen-2-yl)acrylate → ethyl 2-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate
反応式
[N:1]([C:4](=[CH:10][C:11]1[S:12][C:13]([CH3:16])=[CH:14][CH:15]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6])=[N+]=[N-]>C1(C)C=CC=C(C)C=1>[CH3:16][C:13]1[S:12][C:11]2[CH:10]=[C:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])[NH:1][C:15]=2[CH:14]=1参加物
3
実験手順
Ethyl 2-azido-3-(5-methylthiophen-2-yl)acrylate (3.38 g) was dissolved in m-xylene (30 mL) and the mixture was heated at reflux for 1 hour. The reaction solution was concentrated under reduced pressure. To the residue was added n-hexane and the residue was washed with n-hexane. The solid was collected by filtration, and dried under reduced pressure to give the title compound (2.56 g).
後処理
- temperaturethe mixture was heated
- temperatureat reflux for 1 hour
- concentrationThe reaction solution was concentrated under reduced pressure
- additionTo the residue was added n-hexane
- washthe residue was washed with n-hexane
- filtrationThe solid was collected by filtration
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-98005136887b4bbd8f6d888542a7406e
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09115144B2
反応ノート
読み込み中…