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5'-Bromo-2'-hydroxyacetophenone → 1'-Phenyl-6-bromo-spiro[chromane-2,4'-piperidine]-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5'-Bromo-2'-hydroxyacetophenone | HCID 95991 | — |
| 反応物 | 1-Phenyl-4-piperidinone | HCID 413009 | — |
| 反応物 | (E)-3-{1'-tert-butoxycarbonyl-4-oxo-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester | HCID 52952087 | — |
| 生成物 | 1'-Phenyl-6-bromo-spiro[chromane-2,4'-piperidine]-4-one | HCID 66932220 | — |
反応手順
1′-Phenyl-6-bromo-spiro[chromane-2,4′-piperidine]-4-one was synthesized according to the procedure for preparation of Intermediate 1, Step A, using 1-phenyl-piperidin-4-one (607 mg, 3.47 mmol) and 2-hydroxy-5-bromoacetophenone (746 mg, 3.47 mmol), giving 650 mg as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09115148B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-c0950ea8371547d0926ea53da7c061be |
| 出典メモ | uspto-grants-2015_08 |