化工社化工社 化学情報印刷レポート · 研究参考用
Tetrahydrofuran → 2,6-Di-tert-butyl4-trimethylsilanylethynyl-phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Trimethylsilylacetylene | HCID 66111 | — |
| 反応物 | 4-Bromo-2,6-di-tert-butylphenol | HCID 70829 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 触媒 | HCID 178418476 | HCID 178418476 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | 2,6-Di-tert-butyl4-trimethylsilanylethynyl-phenol | HCID 22568924 | — |
反応手順
Following General Procedure D and using 4-bromo-2,6-di-t-butyl-phenol (1.43 g, 5 mmol), triethyl amine (1 5 mL), anhydrous tetrahydrofuran (15 mL), copper(I)iodide (0.06 g, 0.31 mmol), trimethylsilyl acetylene (4.9 g, 50 mmol) and dichlorobis(triphenylphosphine)palladium(II) (0.18 g, 0.26 mmol) followed by flash column chromatography over silica gel (230-400 mesh) using hexane as eluent, the title compound was obtained (1.35 g, 90%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06713647B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-899ac0dc05fe436dbde62e7c4a803301 |
| 出典メモ | uspto-grants-2004_03 |