関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | N-Methyl-4-anisidine | HCID 22250 | — |
| 反応物 | 2-Bromoethyl methyl ether | HCID 80972 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-methoxy-N-(2-methoxyethyl)-N-methylaniline | HCID 11843740 | 84.3% |
反応手順
To a stirred solution of 1.00 g (7.29 mmol) N-methyl-p-anisidine in 15 ml acetonitrile at 0° C. were added dropwise 1.36 ml (8.02 mmol) N-ethyldiisopropylamine and 1.01 g (7.29 mmol) 2-bromoethyl methyl ether. The mixture was heated at 80° C. for 2 days and then concentrated in vacuo. Flash chromatography (1/9 ethyl acetate/hexane) afforded 1.20 g (84%) (2-methoxy-ethyl)-(4-methoxy-phenyl)-methyl-amine as an orange oil. ES-MS m/e (%): 196 (M+H+, 100).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06713499B2 |
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| 出典データセット | uspto-grants-2004_03 |
|---|
| ORD ID | ord-9787000faa6f4ac79af27da87f73a7f1 |
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| 出典メモ | uspto-grants-2004_03 |
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