Benzoyl isothiocyanate → 1-Benzoyl-3-{2-methoxy-5-[(2-methoxy-ethyl)-methyl-amino]-phenyl}-thiourea

HRID 51840

反応式

HRID 51840 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:11][CH2:12][O:13][CH3:14])[CH3:10])=[CH:5][C:4]=1[NH2:15].[C:16]([N:24]=[C:25]=[S:26])(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>CC(C)=O>[C:16]([NH:24][C:25]([NH:15][C:4]1[CH:5]=[C:6]([N:9]([CH2:11][CH2:12][O:13][CH3:14])[CH3:10])[CH:7]=[CH:8][C:3]=1[O:2][CH3:1])=[S:26])(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

4

反応物 2

HCID 68284Benzoyl isothiocyanateHCID 227369974-methoxy-N1-(2-methoxy-ethyl)-N1-methyl-benzene-1,3-diamine

生成物 1

HCID 220157361-Benzoyl-3-{2-methoxy-5-[(2-methoxy-ethyl)-methyl-amino]-phenyl}-thiourea収率 61.1%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒2 回

実験手順

To a stirred solution of 1.89 g (8.99 mmol) 4-methoxy-N1-(2-methoxy-ethyl)-N1-methyl-benzene-1,3-diamine in 60 ml acetone was added dropwise a solution of 1.38 ml (10.3 mmol) benzoyl isothiocyanate in 30 ml acetone and stirring continued at room temperature for 30 minutes. The mixture was then concentrated in vacuo. Trituration in ether afforded 2.05 g (61%) 1-benzoyl-3-{2-methoxy-5-[(2-methoxy-ethyl)-methyl-amino]-phenyl}-thiourea as a yellow solid. ES-MS m/e ((Y)): 374 (M+H+, 100).

後処理

  1. concentrationThe mixture was then concentrated in vacuo

出典と根拠

ORDレコード
ord-0697fc9ae5cc4f7d92b2d26b6b40a87e
出典データセット
uspto-grants-2004_03
特許番号
US06713499B2

関連ノート

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