Hydrochloric Acid → (4-Methoxy-benzothiazol-2-yl)-carbamic acid methyl ester

関与物質

反応手順

To a stirred solution of 23.6 g (131 mmol) 2-amino-4-methoxybenzothiazole and 12.6 ml (157 mmol) pyridine in 230 ml dichloromethane at 0° C. was added dropwise 10.6 ml (137 mmol) methyl chloroformate and stirring continued for 1 hour. The mixture was then poured onto 1 M hydrochloric acid and the organic phase was separated, washed with brine, dried over sodium sulfate, and concentrated in vacuo to afford 31.0 g (99%) (4-methoxy-benzothiazol-2-yl)-carbamic acid methyl ester as a white solid. ES-MS m/e (%): 239 (M+H+, 100).

情報源と証拠