化工社化工社 化学情報印刷レポート · 研究参考用
4-Fluorobenzoic Acid → 4-Fluoro-N-[4-methoxy-7-(methyl-pyridin-2-ylmethyl-amino)-benzothiazol-2-yl]-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Fluorobenzoic Acid | HCID 9973 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 2-(Bromomethyl)pyridine hydrobromide | HCID 2734720 | — |
| 反応物 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 反応物 | 4-methoxy-N7-methyl-benzothiazole-2,7-diamine | HCID 22736978 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-Fluoro-N-[4-methoxy-7-(methyl-pyridin-2-ylmethyl-amino)-benzothiazol-2-yl]-benzamide | HCID 22736983 | — |
反応手順
From 4-methoxy-N7-methyl-benzothiazole-2,7-diamine with potassium carbonate and 2-(bromomethyl)pyridine hydrobromide in DMF, then treatment with 4-fluoro-benzoic acid, HATU and N-ethyldiisopropylamine in THF. ES-MS m/e (%): 423 (M+H+, 100).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06713499B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-c5ed0a147f8c4cc5b2b6aa8bb1ace50b |
| 出典メモ | uspto-grants-2004_03 |