Hydrochloric Acid → 2,2,2-Trifluoro-1-(piperidin-4-yl)ethan-1-ol hydrochloride
反応式
[F:1][C:2]([F:23])([F:22])[CH:3]([CH:9]1[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1)[O:4][Si](C)(C)C.[ClH:24].CCOCC>C(Cl)Cl.CO>[ClH:24].[F:23][C:2]([F:1])([F:22])[CH:3]([CH:9]1[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]1)[OH:4]参加物
6
実験手順
To a solution of tert-butyl 4-(2,2,2-trifluoro-1-(trimethylsilyloxy)ethyl)piperidine-1-carboxylate (1.6 g, 4.50 mmol) in DCM (9 mL) and MeOH (1 mL) was added 2 M HCl in ether (11.25 mL, 22.51 mmol). The reaction was stirred at RT for 16 hours. The precipitate that formed was collected by vacuum filtration, washed with diethyl ether, and dried in vacuo to generate 2,2,2-trifluoro-1-(piperidin-4-yl)ethanol hydrochloride as a white powder (0.83 g, 84% yield).
後処理
- customThe precipitate that formed
- filtrationwas collected by vacuum filtration
- washwashed with diethyl ether
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-3e9fe27fbeb64672a506e9f4da0f6a78
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09115127B2
反応ノート
読み込み中…