Hydrochloric Acid → 2-(Azetidin-3-yl)propan-2-ol hydrochloride
反応式
[OH:1][C:2]([CH:5]1[CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1)([CH3:4])[CH3:3].[ClH:16].O1CCOCC1>C(Cl)Cl>[ClH:16].[NH:7]1[CH2:8][CH:5]([C:2]([OH:1])([CH3:4])[CH3:3])[CH2:6]1参加物
5
実験手順
To a solution of tert-butyl 3-(2-hydroxypropan-2-yl)azetidine-1-carboxylate (0.87 g, 4.04 mmol) in DCM (15 mL) at 0° C. was added 4 M HCl in dioxane (8.08 mL, 16.16 mmol) dropwise. The reaction was stirred overnight at RT. The reaction mixture was concentrated and dried in vacuo to generate 2-(azetidin-3-yl)propan-2-ol hydrochloride as a brown solid (0.44 g, 71.8% yield).
後処理
- concentrationThe reaction mixture was concentrated
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-44cd91c7a6ef45918a21832f7c7fd2b5
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09115127B2
反応ノート
読み込み中…