Hydrochloric Acid → 2-(Pyrrolidin-3-yl)propan-2-ol hydrochloride

HRID 518719ノート

反応式

HRID 518719 の反応式
[OH:1][C:2]([CH:5]1[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1)([CH3:4])[CH3:3].[ClH:17].O1CCOCC1>C(Cl)Cl.CCOC(C)=O>[ClH:17].[NH:7]1[CH2:8][CH2:9][CH:5]([C:2]([OH:1])([CH3:4])[CH3:3])[CH2:6]1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 66728723Tert-butyl 3-(2-hydroxypropan-2-yl)pyrrolidine-1-carboxylate

生成物 1

HCID 667284892-(Pyrrolidin-3-yl)propan-2-ol hydrochloride収率 102%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of tert-butyl 3-(2-hydroxypropan-2-yl)pyrrolidine-1-carboxylate (0.69 g, 3.01 mmol) in DCM (15 mL) and EtOAc (5 mL) was added 4 M HCl in dioxane (3.01 mL, 12.04 mmol). The reaction was stirred overnight at RT and then concentrated to generate 2-(pyrrolidin-3-yl)propan-2-ol hydrochloride as a yellow oil (0.51 g, 102% yield).

後処理

  1. concentrationconcentrated

出典と根拠

ORDレコード
ord-2d24075b429a4f4b95467a7ec54c430c
出典データセット
uspto-grants-2015_08
特許番号
US09115127B2

反応ノート

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