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Iodoethane → N-(7-Diethylamino-4-methoxy-benzothiazol-2-yl)-2-methyl-isonicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodoethane | HCID 6340 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 2-methylpyridine-4-carboxylic Acid Hydrochloride | HCID 2762824 | — |
| 反応物 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 反応物 | 4-Methoxy-1,3-benzothiazole-2,7-diamine | HCID 22736977 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-(7-Diethylamino-4-methoxy-benzothiazol-2-yl)-2-methyl-isonicotinamide | HCID 22736975 | — |
反応手順
From 4-methoxy-benzothiazole-2,7-diamine with potassium carbonate and iodoethane in DMF, then treatment with 2-methyl-isonicotinic acid hydrochloride, HATU and N-ethyldiisopropylamine in THF. ES-MS m/e (%): 371 (M+H+, 100).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06713499B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-ee1dbe3c18084e539f008643ff9aea13 |
| 出典メモ | uspto-grants-2004_03 |