Hydrochloric Acid → HCID 178454572、化合物

HRID 518749

反応式

HRID 518749 の反応式
[NH2:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:15])OC(C)(C)C)[CH2:4][CH2:3]1.[C:16](OC(=O)C(C)C)(=O)[CH:17](C)[CH3:18].[ClH:27].O1CCOCC1>C(Cl)Cl>[ClH:27].[NH2:1][C@@H:2]1[CH2:3][CH2:4][C@H:5]([NH:8][C:9](=[O:15])[CH:17]([CH3:18])[CH3:16])[CH2:6][CH2:7]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 7346Isobutyric anhydrideHCID 312751,4-DioxaneHCID 178418966HCID 178418966、化合物

生成物 1

HCID 178454572HCID 178454572、化合物収率 99%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of tert-butyl cis-4-aminocyclohexylcarbamate (500 mg, 2.333 mmol) in DCM (20 mL) was added isobutyric anhydride (0.407 mL, 2.450 mmol). The solution was stirred overnight at RT. After 16 hours, 4 M HCl in dioxane (2.333 mL, 9.33 mmol) was added, and the reaction was stirred at RT overnight. The resulting white precipitate was collected by vacuum filtration and dried in vacuo to generate N-(cis-4-aminocyclohexyl)isobutyramide hydrochloride as an off-white powder (508 mg, 99% yield).

後処理

  1. waitAfter 16 hours
  2. stirringthe reaction was stirred at RT overnight
  3. filtrationThe resulting white precipitate was collected by vacuum filtration
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-1b50403a11734cafaf032c6addf143c1
出典データセット
uspto-grants-2015_08
特許番号
US09115127B2

関連ノート

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