化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Carbonate → 2-Bromo-N-{4-methoxy-7-[(4-methoxy-benzyl)-methyl-amino]-benzothiazol-2-yl}-isonicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 2-Bromoisonicotinic acid | HCID 222701 | — |
| 反応物 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 反応物 | 4-methoxy-N7-methyl-benzothiazole-2,7-diamine | HCID 22736978 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Bromo-N-{4-methoxy-7-[(4-methoxy-benzyl)-methyl-amino]-benzothiazol-2-yl}-isonicotinamide | HCID 22736989 | — |
反応手順
From 4-methoxy-N7-methyl-benzothiazole-2,7-diamine with potassium carbonate and 4-methoxybenzyl chloride in DMF, then treatment with 2-bromo-isonicotinic acid, HATU and N-ethyldiisopropylamine in THF. ES-MS m/e (%): 515 (M{81Br}+H+, 100), 513 (M{79Br}+H+, 81).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06713499B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-8aa228de6d89408993c0959d3705b3f0 |
| 出典メモ | uspto-grants-2004_03 |