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Thionyl Chloride → 4'-(Trifluoromethyl)-[1,1'-biphenyl]-2-carbonyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 4'-(Trifluoromethyl)(1,1'-biphenyl)-2-carboxylic acid | HCID 55251 | — |
| 生成物 | 4'-(Trifluoromethyl)-[1,1'-biphenyl]-2-carbonyl chloride | HCID 11066000 | 99% |
反応手順
4′-Trifluoromethyl-biphenyl-2-carboxylic acid (25 g, 94 mmol) was combined with thionyl chloride (35 ml, 470 mmol) and the mixture was heated at reflux. After 2 h, the mixture was concentrated under vacuum to afford 26.5 g of the title product as a light yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06713489B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-e31257c66ddc4875b0e298998fa41e5a |
| 出典メモ | uspto-grants-2004_03 |