Triethylamine → 1-Azetidinecarboxylic acid, 2-methyl-3-oxo-, 1,1-dimethylethyl ester

HRID 519092ノート

反応式

HRID 519092 の反応式
[C:1]([O:5][C:6](=[O:15])[NH:7][CH:8]([CH3:14])[C:9](=[O:13])[CH:10]=[N+]=[N-])([CH3:4])([CH3:3])[CH3:2].CCN(CC)CC>C(Cl)Cl.C([O-])(=O)C.[Rh+2].C([O-])(=O)C>[C:1]([O:5][C:6]([N:7]1[CH2:10][C:9](=[O:13])[CH:8]1[CH3:14])=[O:15])([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 2

HCID 8471TriethylamineHCID 56979712tert-butyl N-(4-diazo-3-oxobutan-2-yl)carbamate

生成物 1

HCID 722080901-Azetidinecarboxylic acid, 2-methyl-3-oxo-, 1,1-dimethylethyl ester

試薬・触媒・溶媒 2

HCID 21674Acetic acid, rhodium(2+) salt触媒HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

(3-Diazo-1-methyl-2-oxo-propyl)-carbamic acid tert-butyl ester (0.250 g, 1.17 mmol) was dissolved in anhydrous DCM (6 mL) and Et3N (1.18 mg, 0.012 mmol) was added. The reaction mixture was cooled to 0° C. and rhodium (II) acetate (0.010 g, 0.023 mmol) was added. The reaction mixture was stirred at 0° C. for 1 h then concentrated in vacuo to give 2-methyl-3-oxo-azetidine-1-carboxylic acid tert-butyl ester, which was used in the next step without further purification. TLC (eluting with 20% EtOAc/heptane) Rf=0.3.

後処理

  1. concentrationthen concentrated in vacuo

出典と根拠

ORDレコード
ord-7f93eece9d644fbc8fdf13f5ad91e0fd
出典データセット
uspto-grants-2015_08
特許番号
US09115151B2

反応ノート

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