Ammonia → Ethyl 3-amino-2-phenylpropyl(diethoxymethyl)phosphinate

HRID 5191

反応式

HRID 5191 の反応式
[N+:1]([CH2:4][CH:5]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:6][P:7]([CH:12]([O:16][CH2:17][CH3:18])[O:13][CH2:14][CH3:15])(=[O:11])[O:8][CH2:9][CH3:10])([O-])=O.N.[H][H]>C(O)C.[Ni]>[NH2:1][CH2:4][CH:5]([C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[CH2:6][P:7]([CH:12]([O:16][CH2:17][CH3:18])[O:13][CH2:14][CH3:15])(=[O:11])[O:8][CH2:9][CH3:10]

参加物

6

反応物 3

HCID 222AmmoniaHCID 14362826Ethyl 3-nitro-2-phenylpropyl(diethoxymethyl)phosphinateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 14362832Ethyl 3-amino-2-phenylpropyl(diethoxymethyl)phosphinate

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒2 回

実験手順

A solution of 5.7 g of ethyl 3-nitro-2-phenylpropyl(diethoxymethyl)phosphinate in 60 ml of ethanol is added to 50 g of an 8% solution of ammonia in ethanol. To this are added 9 ml of Raney Nickel and the resulting mixture is hydrogenated at 1 bar until the theoretical amount of hydrogen has been taken up. The mixture is then filtered and the filtrate is concentrated under reduced pressure to give ethyl 3-amino-2-phenylpropyl(diethoxymethyl)phosphinate as a viscous oil, 31 p=+44.4 ppm (CDCl3).

後処理

  1. filtrationThe mixture is then filtered
  2. concentrationthe filtrate is concentrated under reduced pressure

出典と根拠

ORDレコード
ord-7dc71600b17042d78234f99e2162c0fb
出典データセット
uspto-grants-1993_09
特許番号
US05243062

関連ノート

読み込み中…