Hydrochloric Acid → Methyl 3-(2-aminoethyl)-5,6,7,8-tetrahydroindolizine-2-carboxylate hydrochloride

HRID 519260ノート

反応式

HRID 519260 の反応式
[C:1]([CH2:3][C:4]1[N:12]2[C:7]([CH2:8][CH2:9][CH2:10][CH2:11]2)=[CH:6][C:5]=1[C:13]([O:15][CH3:16])=[O:14])#[N:2].[H][H].[ClH:19]>[Pt]=O.C(O)C.C(OCC)(=O)C>[ClH:19].[NH2:2][CH2:1][CH2:3][C:4]1[N:12]2[C:7]([CH2:8][CH2:9][CH2:10][CH2:11]2)=[CH:6][C:5]=1[C:13]([O:15][CH3:16])=[O:14]

参加物

7

反応物 3

HCID 313Hydrochloric AcidHCID 58044124Methyl 3-(cyanomethyl)-5,6,7,8-tetrahydroindolizine-2-carboxylateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 67016117Methyl 3-(2-aminoethyl)-5,6,7,8-tetrahydroindolizine-2-carboxylate hydrochloride

試薬・触媒・溶媒 3

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

Methyl 3-(Cyanomethyl)-5,6,7,8-tetrahydroindolizine-2-carboxylate 101e was hydrogenated with platinum oxide catalyst under 50 psi of hydrogen in ethanol and ethyl acetate in the presence of hydrogen chloride overnight at room temperature to give 101f (380 mg, 1.74 mmol) which was used in directly in the next step.

出典と根拠

ORDレコード
ord-7ca5aa8616744cfa8de5b67e456db499
出典データセット
uspto-grants-2015_08
特許番号
US09115152B2

反応ノート

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