化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Acetamide, 2-(hydroxyimino)-N-phenyl-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Aniline | HCID 6115 | — |
| 反応物 | Chloral | HCID 6407 | — |
| 反応物 | Isatin | HCID 7054 | — |
| 反応物 | Hydroxylamine HCl | HCID 21645 | — |
| 生成物 | Acetamide, 2-(hydroxyimino)-N-phenyl- | HCID 6861488 | — |
反応手順
The isatin derivative (9) can be synthesized, for example, as shown in the following reaction scheme. That is, an aqueous solution obtained by adding chloral and hydroxylammonium chloride to hydrochloride of an aniline derivative (10) as a starting material is reacted for 0.5 to 2 hours with heating at 70° to 110° C. to give an isonitrosoacetanilide derivative, and this product is cyclized with concentrated sulfuric acid and hydrolyzed to give an isatin derivative (9). ##STR10## wherein R1A to R1D are as defined above.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05616441 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-e75f94cdfd09486eb81e090e8b1e9b65 |
| 出典メモ | uspto-grants-1997_04 |