Methyl 3-bromo-1-adamantaneacetate → Methyl 3-phenyl-1-adamantaneacetate

HRID 51983

反応式

HRID 51983 の反応式
Br[C:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][C:4]([CH2:12][C:13]([O:15][CH3:16])=[O:14])([CH2:5]3)[CH2:3]1)[CH2:9]2.[Cl-].[Cl-].[Cl-].[Al+3]>C1C=CC=CC=1>[C:2]1([C:2]23[CH2:11][CH:6]4[CH2:7][CH:8]([CH2:10][C:4]([CH2:12][C:13]([O:15][CH3:16])=[O:14])([CH2:5]4)[CH2:3]2)[CH2:9]3)[CH:11]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 610084Methyl 3-bromo-1-adamantaneacetateHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 53665692Methyl 3-phenyl-1-adamantaneacetate収率 202%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

Methyl 3-bromoadamantaneacetate (80 g) (Aldrich Chemical Co. Milwaukee Wis.) was dissolved in benzene (1.6 L) under nitrogen. Aluminum trichloride (37.12 g) was added portionwise over 75 min. at ambient temperature. The reaction mixture was then quenched by the addition of 0.5M phosphoric acid (1.6 L). The layers were separated and the organic layer was dried over sodium sulfate, filtered, and evaporated in vacuo to give methyl 3-phenyl-1-adamantaneacetate (80 g).

後処理

  1. customThe reaction mixture was then quenched by the addition of 0.5M phosphoric acid (1.6 L)
  2. customThe layers were separated
  3. dry with materialthe organic layer was dried over sodium sulfate
  4. filtrationfiltered
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-33797f736a214462ba6cf92a008f2560
出典データセット
uspto-grants-1997_04
特許番号
US05616505

関連ノート

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