Benzyl 1-benzoyl-5-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-ethoxycarbonyl-2-methylindol-4-carboxylate → HCID 19962783、化合物

HRID 52017ノート

反応式

HRID 52017 の反応式
[C:1]([N:9]1[C:17]2[CH:16]=[CH:15][C:14]([O:18][C:19]3[N:24]=[C:23]([O:25][CH3:26])[CH:22]=[C:21]([O:27][CH3:28])[N:20]=3)=[C:13]([C:29]([O:31]CC3C=CC=CC=3)=[O:30])[C:12]=2[C:11]([C:39]([O:41][CH2:42][CH3:43])=[O:40])=[C:10]1[CH3:44])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(OCC)(=O)C.[C].[Pd]>[C:1]([N:9]1[C:17]2[CH:16]=[CH:15][C:14]([O:18][C:19]3[N:24]=[C:23]([O:25][CH3:26])[CH:22]=[C:21]([O:27][CH3:28])[N:20]=3)=[C:13]([C:29]([OH:31])=[O:30])[C:12]=2[C:11]([C:39]([O:41][CH2:42][CH3:43])=[O:40])=[C:10]1[CH3:44])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 1

HCID 19962759Benzyl 1-benzoyl-5-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-ethoxycarbonyl-2-methylindol-4-carboxylate

生成物 1

HCID 19962783HCID 19962783、化合物収率 97%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8857Ethyl Acetate溶媒

実験手順

1.6 g of benzyl 1-benzoyl-5-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-ethoxycarbonyl-2-methylindol-4-carboxylate was dissolved in 50 ml of ethyl acetate, and 0.1 g of 10% palladium carbon was added thereto. Then, catalytic reduction was conducted. Insoluble matters were filtered off, and then filtrate was concentrated under reduced pressure. The residue thereby obtained was washed with isopropyl ether to obtain 1.28 g (yield: 97%) of the desired compound. mp: 113°-115° C.

後処理

  1. filtrationInsoluble matters were filtered off
  2. concentrationfiltrate was concentrated under reduced pressure
  3. customThe residue thereby obtained
  4. washwas washed with isopropyl ether

出典と根拠

ORDレコード
ord-842237a3d11e4c5aa8d4605933cc7330
出典データセット
uspto-grants-1997_04
特許番号
US05616537

反応ノート

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