Citric Acid → Apomorphine

HRID 520276

反応式

HRID 520276 の反応式
C(O)[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.[CH3:13][N:14]1[C@@H:23]2[CH2:24][C:25]3[CH:30]=[CH:29][C:28]([OH:31])=[C:27]([OH:32])[C:26]=3[C:21]3[C:22]2=[C:17]([CH:18]=[CH:19][CH:20]=3)[CH2:16][CH2:15]1.Cl.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>O>[CH3:13][N:14]1[C@@H:23]2[CH2:24][C:25]3[CH:30]=[CH:29][C:28]([OH:31])=[C:27]([OH:32])[C:26]=3[C:21]3[C:22]2=[C:17]([CH:18]=[CH:19][CH:20]=3)[CH2:16][CH2:15]1

参加物

5

反応物 3

HCID 311Citric AcidHCID 6251MannitolHCID 94104H-Dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride (1:1), (6aR)-2 回

生成物 1

HCID 6005Apomorphine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Gelatin and mannitol are dispersed in purified water and mixed thoroughly (i.e., using a vacuum mixer) and homogenized. Apomorphine hydrochloride is added and the mixture was again homogenized to ensure complete dissolution of the apomorphine hydrochloride. The pH of the solution is adjusted to about 3.0 (i.e., by addition of a suitable acid, such as citric acid). The solution is then poured onto a sheet and dried in a heated oven.

後処理

  1. additionmixed thoroughly (i.e.
  2. stirringthe mixture was again homogenized
  3. additionby addition of a suitable acid
  4. additionThe solution is then poured onto a sheet
  5. customdried in a heated oven

出典と根拠

ORDレコード
ord-1df9c2a8030f4e2683f6d2d94be875ff
出典データセット
uspto-grants-2016_05
特許番号
US09326981B2

関連ノート

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