Methyl 2,6-dibromohexanoate → Methyl 2-(acetylthio)-6-bromohexanoate
反応式
[C:1](=[S:4])([O-:3])[CH3:2].[K+].Br[CH:7]([CH2:12][CH2:13][CH2:14][CH2:15][Br:16])[C:8]([O:10][CH3:11])=[O:9]>CS(C)=O>[C:1]([S:4][CH:7]([CH2:12][CH2:13][CH2:14][CH2:15][Br:16])[C:8]([O:10][CH3:11])=[O:9])(=[O:3])[CH3:2]参加物
4
実験手順
Neat potassium ethanethioate (571 mg, 5 mmol) was added to a solution of methyl 2,6-dibromohexanoate (1440 mg, 5 mmol) in DMSO (5 mL) and the mixture was stirred at rt overnight. The reaction was quenched with water and extracted with ether, washed with water, brine and dried (MgSO4). The crude isolate was purified by silica gel FCC (DCM) to afford methyl 2-(acetylthio)-6-bromohexanoate as a clear oil.
後処理
- customThe reaction was quenched with water
- extractionextracted with ether
- washwashed with water, brine
- dry with materialdried (MgSO4)
- customThe crude isolate
- customwas purified by silica gel FCC (DCM)
出典と根拠
- ORDレコード
- ord-003d7b7362c84dccbe7552a9d804c524
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09326973B2
反応ノート
読み込み中…