P-Phenylenediamine → 4-(4'-Aminoanilino)-6,7-dimethoxyquinazoline hydrochloride

反応式

[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[C:16]1([NH2:23])[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=1>>[ClH:1].[NH2:22][C:19]1[CH:20]=[CH:21][C:16]([NH:23][C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=3)[N:5]=[CH:4][N:3]=2)=[CH:17][CH:18]=1

参加物

反応物 2

HCID 7814P-Phenylenediamine

HCID 27693644-Chloro-6,7-dimethoxyquinazoline

生成物 1

HCID 199632054-(4'-Aminoanilino)-6,7-dimethoxyquinazoline hydrochloride収率 85%

実験手順

Using an analogous procedure to that described in Example 74, 4-chloro-6,7-dimethoxyquinazoline was reacted with 1,4-phenylenediamine to give 4-(4'-aminoanilino)-6,7-dimethoxyquinazoline hydrochloride in 85% yield, m.p. 274°-276° C.

出典と根拠

ORDレコード: ord-2bf3a55ffb9740a8a419c4c9f340bd88
出典データセット: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05616582

反応ノート

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