Acetic Anhydride → 8-Nitro-2-(3-(trifluoromethyl)phenyl)quinolin-4-yl acetate

HRID 520461ノート

反応式

HRID 520461 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[NH:12][C:11]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=1)=[CH:10][C:9]2=[O:24])([O-:3])=[O:2].C(N(CC)CC)C.[CH3:32][C:33](OC(C)=O)=[O:34].C([O-])(O)=O.[Na+]>C(Cl)Cl>[C:33]([O:24][C:9]1[C:8]2[C:13](=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=[CH:6][CH:7]=2)[N:12]=[C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:21])[F:22])[CH:15]=2)[CH:10]=1)(=[O:34])[CH3:32]

参加物

6

反応物 4

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 516892Sodium BicarbonateHCID 585529228-nitro-2-(3-(trifluoromethyl)phenyl)quinolin-4(1H)-one

生成物 1

HCID 585528568-Nitro-2-(3-(trifluoromethyl)phenyl)quinolin-4-yl acetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 8-nitro-2-(3-(trifluoromethyl)phenyl)quinolin-4(1H)-one 37 (707 mg, 2.11 mmol), triethylamine (1 mL), and Ac2O (0.7 mL) in CH2Cl2 (10 mL) was stirred at room temperature for 16 h. Sat. aq NaHCO3 (10 mL) was added, and the reaction extracted with CH2Cl2. The combined organic layers were dried (MgSO4) and concentrated to give 38.

後処理

  1. extractionthe reaction extracted with CH2Cl2
  2. dry with materialThe combined organic layers were dried (MgSO4)
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-a2d89c3bf66c4a74b48425fa29bee2a5
出典データセット
uspto-grants-2016_05
特許番号
US09326986B2

反応ノート

読み込み中…