関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 4-Aminonicotinic acid | HCID 319979 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-Amino-5-bromopyridine-3-carboxylic acid | HCID 21530494 | 84% |
反応手順
A sealed tube was charged with 4-aminonicotinic acid 45 (8.00 g, 57.9 mmol), acetic acid (75 mL) and water (75 mL). The reaction was heated at 75° C. and stirred vigorously until homogeneous. After cooling to 50° C., bromine (10.0 mL, 195 mmol) was added and stirring continued for 16 h. Upon cooling to 0° C., the resulting orange precipitate was collected by filtration, rinsed with H2O, and dried under vacuum to give 46 (10.5 g, 84% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09326986B2 |
|---|
| 出典データセット | uspto-grants-2016_05 |
|---|
| ORD ID | ord-e6fe524ad1694ba8934cf5ce81187a03 |
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| 出典メモ | uspto-grants-2016_05 |
|---|
