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4-Nitrobenzenesulfonyl chloride → 4-Bromo-1-[(4-nitrophenyl)sulfonyl]-1H-indole-6-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Nitrobenzenesulfonyl chloride | HCID 7404 | — |
| 反応物 | 2-((1,1-Dimethylethyl)imino)-N,N-diethylhexahydro-1,3-dimethyl-2lambda5-1,3,2-diazaphosphorin-2-amine | HCID 3513851 | — |
| 反応物 | 4-bromo-1H-indole-6-carbonitrile | HCID 24728883 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Bromo-1-[(4-nitrophenyl)sulfonyl]-1H-indole-6-carbonitrile | HCID 66692272 | — |
反応手順
4-Bromo-1H-indole-6-carbonitrile (207 mg), PS-BEMP (900 mg) and 4-nitrobenzenesulfonyl chloride (380 mg) were weighed to a round bottom flask, then N,N-Dimethylformamide (4 ml) was added and the reaction was stirred at RT. The reaction was filtered and washed with DMF. The DMF was evaporated and the residue was dissolved in DCM:methanol and passed through a 5 g SAX cartridge (preconditioned with methanol) washing with DCM:methanol. The residue was evaporated to afford the title compound, 360 mg as a pale orange solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09326987B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-b012c838402e4d64b66e3aab0f2606b9 |
| 出典メモ | uspto-grants-2016_05 |