Pyrazole-4-carboxylic acid → N-{4-[4-(1-Pyrrolidinylmethyl)-2-pyridyloxy]-cis-2-butenyl}pyrazole-4-carboxamide
反応式
[N:1]1([CH2:6][C:7]2[CH:12]=[CH:11][N:10]=[C:9]([O:13][CH2:14]/[CH:15]=[CH:16]\[CH2:17][NH2:18])[CH:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:19]1[CH:23]=[C:22]([C:24](O)=[O:25])[CH:21]=[N:20]1>>[N:1]1([CH2:6][C:7]2[CH:12]=[CH:11][N:10]=[C:9]([O:13][CH2:14]/[CH:15]=[CH:16]\[CH2:17][NH:18][C:24]([C:22]3[CH:23]=[N:19][NH:20][CH:21]=3)=[O:25])[CH:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1参加物
3
実験手順
Following a procedure similar to that described in Example 13, but using 4-[4-(1-pyrrolidinylmethyl)-2-pyridyloxy]-cis-2-butenylamine and 4-pyrazolecarboxylic acid as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as a white powder, melting at 57°-61° C., in a 34% yield.
出典と根拠
- ORDレコード
- ord-65cbfa9f3d2f43d8a0423c90930c102f
- 出典データセット
- uspto-grants-1997_04