Aniline → 6-Bromo-4-hydroxy-3-(phenylamino)quinolin-2(1H)-one

HRID 520848ノート

反応式

HRID 520848 の反応式
FC(F)(F)S([O-])(=O)=O.[Br:9][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[NH:16][C:15](=[O:20])[C:14]([I+]C1C=CC=CC=1)=[C:13]2[OH:28].[NH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>C(Cl)Cl>[Br:9][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[NH:16][C:15](=[O:20])[C:14]([NH:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[C:13]2[OH:28]

参加物

4

反応物 2

HCID 6115AnilineHCID 86715456(6-Bromo-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)(phenyl) iodoniumtrifluoromethane sulfonate2 回

生成物 1

HCID 867154586-Bromo-4-hydroxy-3-(phenylamino)quinolin-2(1H)-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of (6-bromo-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)(phenyl)iodoniumtrifluoromethane sulfonate (1.40 g, 2.36 mmol, Intermediate 8, step b) and aniline (1 mL) was stirred for 4 hours at room temperature. To this was added DCM and the resulting suspension was filtered. The solid was washed first with DCM followed by water and air dried under vacuum at 50° C. to yield the title compound.

後処理

  1. filtrationthe resulting suspension was filtered
  2. washThe solid was washed first with DCM
  3. customdried under vacuum at 50° C.

出典と根拠

ORDレコード
ord-24bf5f5f59624fb3bf2cb0689e3133b2
出典データセット
uspto-grants-2016_05
特許番号
US09328095B2

反応ノート

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