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Isobutyryl chloride → N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-2-[2-(2-methylpropionyloxy)ethylthio]acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isobutyryl chloride | HCID 62325 | — |
| 反応物 | N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-2-(2-hydroxyethylthio)acetamide | HCID 67725880 | — |
| 生成物 | N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-2-[2-(2-methylpropionyloxy)ethylthio]acetamide | HCID 67725820 | 73% |
反応手順
Following a procedure similar to that described in Example 7, but using N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-2-(2-hydroxyethylthio)acetamide (prepared as described in Example 1) and 2-methylpropionyl chloride as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained in a 73% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05616579 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-37f66a6f2d5848f6aa6921bcb005933c |
| 出典メモ | uspto-grants-1997_04 |