Acetic Anhydride → Acetic acid 3-(2-hydroxy-ethyl)-phenyl ester

HRID 521511

反応式

HRID 521511 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][OH:10])[CH:5]=[CH:6][CH:7]=1.C(=O)([O-])O.[Na+].[C:16](OC(=O)C)(=[O:18])[CH3:17]>O1CCOCC1.O>[OH:10][CH2:9][CH2:8][C:4]1[CH:3]=[C:2]([O:1][C:16](=[O:18])[CH3:17])[CH:7]=[CH:6][CH:5]=1

参加物

6

反応物 3

HCID 7918Acetic AnhydrideHCID 834043-Hydroxyphenethyl alcoholHCID 516892Sodium Bicarbonate

生成物 1

HCID 67076782Acetic acid 3-(2-hydroxy-ethyl)-phenyl ester

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

2-(3-Hydroxyphenyl)ethanol (400 mg, 2.90 mmol) was dissolved in a mixture of 4 ml of dioxane and 4 ml of water, and sodium hydrogencarbonate (2.43 g, 29 mmol) was added followed by acetic anhydride (2.96 g, 29 mmol) with ice cooling. The mixture was stirred overnight at room temperature and then partitioned between 2 N hydrochloric acid and EA. The aqueous phase was extracted with EA, the combined organic phases were dried over sodium sulfate and evaporated to dryness to yield the crude title compound which was used without further purification.

後処理

  1. additionwas added
  2. custompartitioned between 2 N hydrochloric acid and EA
  3. extractionThe aqueous phase was extracted with EA
  4. dry with materialthe combined organic phases were dried over sodium sulfate
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-1eee8947a8e040e8a10209160bf2a857
出典データセット
uspto-grants-2016_05
特許番号
US09328071B2

関連ノート

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