化工社化工社 化学情報印刷レポート · 研究参考用
Diazomethane → methyl 1H-indole-4-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diazomethane | HCID 9550 | — |
| 反応物 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 反応物 | Indole-4-carboxylic acid | HCID 595229 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | methyl 1H-indole-4-carboxylate | HCID 2733668 | 98% |
反応手順
To a solution of indole-4-carboxylic acid (506 mg, 3.14 mmol) dissolved in a mixture of methanol (5 mL) and diethyl ether (10 mL) was added ethereal diazomethane until disappearance of starting acid was indicated by TLC. Anhydrous magnesium sulfate was then added and the solution filtered and concentrated in vacuo. Flash chromatography on 10 g of Merck silica gel eluted with 2:1, chloroform:hexanes, followed by 10:1, chloroform:diethyl ether afforded the title compound (540 mg, 98%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05616591 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-5d171451110d4124a3baf16313134425 |
| 出典メモ | uspto-grants-1997_04 |