Dimethylformamide → 4-Chloro-2-ethylsulfanylbenzaldehyde

HRID 521666

反応式

HRID 521666 の反応式
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4](F)[CH:3]=1.[CH2:11]([SH:13])[CH3:12].C(=O)([O-])[O-].[K+].[K+].CN(C=O)C>O>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([S:13][CH2:11][CH3:12])[CH:3]=1

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 6343EthanethiolHCID 11430Potassium CarbonateHCID 27249084-Chloro-2-fluorobenzaldehyde

生成物 1

HCID 1148635404-Chloro-2-ethylsulfanylbenzaldehyde

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 4.0 g of 4-chloro-2-fluorobenzaldehyde, 2.05 ml of ethanethiol, 3.82 g of potassium carbonate and 6 ml of DMF was stirred at room temperature for 6 hours, and was allowed to stand overnight. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, then dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 3.57 g of 4-chloro-2-ethylsulfanylbenzaldehyde.

後処理

  1. waitto stand overnight
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-3ecac01b7d224c75b9a09b7aa985bcb2
出典データセット
uspto-grants-2016_05
特許番号
US09328121B1

関連ノート

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