6-Bromo-5-methyl-2-trifluoromethyl-2,3-dihydroimidazo [1,2-a]pyridin-2-ol hydrobromide → 6-Bromo-5-methyl-2-trifluoromethylimidazo[1,2-a]pyridine
反応式
Br.[Br:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([CH2:10][C:11]([C:14]([F:17])([F:16])[F:15])(O)[N:12]=2)[C:8]=1[CH3:9]>C(O)C>[Br:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([CH:10]=[C:11]([C:14]([F:16])([F:17])[F:15])[N:12]=2)[C:8]=1[CH3:9]参加物
3
実験手順
A mixture of 3.29 g of 6-bromo-5-methyl-2-trifluoromethyl-2,3-dihydroimidazo[1,2-a]pyridin-2-ol hydrobromide and 10 ml of ethanol was stirred under heat-reflux for 3 hours. The cooled reaction mixture was concentrated under reduced pressure, then water was added, and the mixture was extracted with ethyl acetate. The mixture was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain 2.72 g of 6-bromo-5-methyl-2-trifluoromethylimidazo[1,2-a]pyridine.
後処理
- temperatureunder heat-reflux for 3 hours
- customThe cooled reaction mixture
- concentrationwas concentrated under reduced pressure
- additionwater was added
- extractionthe mixture was extracted with ethyl acetate
- dry with materialThe mixture was dried over anhydrous sodium sulfate
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-94deecfee1c445ada316de5ed67e045c
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09328121B1
反応ノート
読み込み中…