1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) → methyl 5-(4-(tert-butoxycarbonyl(3-nitrophenyl)amino)pyridine-2-yl)-1H-pyrrole-3-carboxylate

HRID 521765ノート

反応式

HRID 521765 の反応式
Cl[C:2]1[CH:7]=[C:6]([N:8]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([N+:22]([O-:24])=[O:23])[CH:17]=2)[C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])[CH:5]=[CH:4][N:3]=1.CC1(C)C(C)(C)OB([C:33]2[NH:37][CH:36]=[C:35]([C:38]([O-:40])=[O:39])[CH:34]=2)O1.[CH3:42]C1(C)C2C(=C(P(C3C=CC=CC=3)C3C=CC=CC=3)C=CC=2)OC2C(P(C3C=CC=CC=3)C3C=CC=CC=3)=CC=CC1=2>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[C:11]([O:10][C:9]([N:8]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([N+:22]([O-:24])=[O:23])[CH:17]=1)[C:6]1[CH:5]=[CH:4][N:3]=[C:2]([C:33]2[NH:37][CH:36]=[C:35]([C:38]([O:40][CH3:42])=[O:39])[CH:34]=2)[CH:7]=1)=[O:15])([CH3:14])([CH3:13])[CH3:12]

参加物

5

反応物 3

HCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)HCID 58167904tert-Butyl 2-chloropyridin-4-yl(3-nitrophenyl)carbamateHCID 866515565-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-3-carboxylate

生成物 1

HCID 67042276methyl 5-(4-(tert-butoxycarbonyl(3-nitrophenyl)amino)pyridine-2-yl)-1H-pyrrole-3-carboxylate収率 543.8%

試薬・触媒・溶媒 1

HCID 9811564Bis(dibenzylideneacetone)palladium触媒

反応条件

温度
105 °C

実験手順

A mixture of tert-Butyl 2-chloropyridin-4-yl(3-nitrophenyl)carbamate (3.65 g, 10.43 mmol), methyl-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-3-carboxylate (5.48 g, 21.82 mmol), xantphos (0.72 g, 1.25 mmol) and Pd2dba3 (0.72 g, 0.79 mmol) was added to a thick walled reaction vessel and purged with N2. A solution of 2M K2CO3 (8.76 mL) was added, followed by dioxane (67 mL). The reaction vessel was sealed and the mixture stirred at 105° C. for 18 h. The reaction vessel was cooled to rt and the mixture was filtered over celite, washing with EtOAc. The filtrate was concentrated to afford a dark oil, which was purified via column chromatography eluting with 30-50% EtOAc/hexanes to afford methyl 5-(4-(tert-butoxycarbonyl(3-nitrophenyl)amino)pyridine-2-yl)-1H-pyrrole-3-carboxylate (2.98 g, 65% yield) as an orange oil.

後処理

  1. additionwas added to a thick walled reaction vessel
  2. custompurged with N2
  3. additionA solution of 2M K2CO3 (8.76 mL) was added
  4. customThe reaction vessel was sealed
  5. temperatureThe reaction vessel was cooled to rt
  6. filtrationthe mixture was filtered over celite
  7. washwashing with EtOAc
  8. concentrationThe filtrate was concentrated
  9. customto afford a dark oil, which
  10. customwas purified via column chromatography
  11. washeluting with 30-50% EtOAc/hexanes

出典と根拠

ORDレコード
ord-4ec5e8df3ab54471b60320df69684ed0
出典データセット
uspto-grants-2016_05
特許番号
US09328103B2

反応ノート

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