関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-Pyridinecarboxaldehyde | HCID 10371 | — |
| 反応物 | Chloroform methanol | HCID 21584188 | — |
| 反応物 | HCID 178418439 | HCID 178418439 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Pyridin-3-yl(thiophen-2-yl)methanol | HCID 650499 | 62.2% |
反応手順
To a solution of 3-pyridinecarboxaldehyde (5.0 mL, 53 mmol) in THF at -78° C. was added 2-thienyllithium (1.0M in THF. 64 mL, 64 mmol) and the reaction mixture was stirred for 2 hours at -78° C. The reaction mixture was quenched with saturated aqueous NH4Cl and extracted with ether. The organic phase was dried over MgSO4, filtered, and concentrated in vacuo. Chromatography on silica gel (5%, then 10% methanol/CHCl3) gave 2-(3-pyridylhydroxymethyl)thiophene (6.30 g, 62% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05616596 |
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| 出典データセット | uspto-grants-1997_04 |
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| ORD ID | ord-821002a002e645fc8b3d520076f6a82a |
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| 出典メモ | uspto-grants-1997_04 |
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