(2-Chloro-3-fluorophenyl)boronic acid → 2-(2-Chloro-3-fluorophenyl)thiazole-4-carboxylic acid

反応式

FC1C=C(OC)C=C(F)C=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1.[Cl:19][C:20]1[C:25]([F:26])=[CH:24][CH:23]=[CH:22][C:21]=1B(O)O>>[Cl:19][C:20]1[C:25]([F:26])=[CH:24][CH:23]=[CH:22][C:21]=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1

参加物

反応物 2

HCID 22309459(2-Chloro-3-fluorophenyl)boronic acid

HCID 834100432-(2,6-Difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid

生成物 1

HCID 833185872-(2-Chloro-3-fluorophenyl)thiazole-4-carboxylic acid

実験手順

Following the procedure of Intermediate 104, replacing 2,6-difluoro-4-methoxyphenylboronic acid with (2-chloro-3-fluorophenyl)boronic acid gave the title compound.

出典と根拠

ORDレコード: ord-aab714d220784f3992b8a4ac34e4f964
出典データセット: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09328106B2

反応ノート

読み込み中…