Ethyl bromopyruvate → Ethyl 2-(5-bromo-2-fluoro-phenyl)thiazole-4-carboxylate
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:11])=[C:6]([C:8](=[S:10])[NH2:9])[CH:7]=1.Br[CH2:13][C:14](=O)[C:15]([O:17][CH2:18][CH3:19])=[O:16]>C(O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:11])=[C:6]([C:8]2[S:10][CH:13]=[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[N:9]=2)[CH:7]=1参加物
4
反応条件
- 温度
- 80 °C
実験手順
A mixture of 5-bromo-2-fluoro-benzenecarbothioamide (11.8 mmol, 2840 mg) and ethyl bromopyruvate (1.05 equiv., 12.4 mmol, 1.56 mL) in ethanol (30 mL) was heated at 80° C. overnight. The mixture was concentrated and the residue was purified on silica eluted with 0 to 20% EtOAc in Heptane to afford ethyl 2-(5-bromo-2-fluoro-phenyl)thiazole-4-carboxylate (2960 mg, 76.14% Yield) as a clear oil.
後処理
- concentrationThe mixture was concentrated
- customthe residue was purified on silica
- washeluted with 0 to 20% EtOAc in Heptane
出典と根拠
- ORDレコード
- ord-f2e99a77ae9a42b4ac7ce163951d8682
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09328106B2
反応ノート
読み込み中…