5-(Tert-butoxycarbonylamino)-2-(2,3-difluorophenyl)thiazole-4-carboxylic acid → 5-Amino-N-[5-[(2S,5R,6R)-5-amino-6-fluoro-oxepan-2-yl]-1-methyl-pyrazol-4-yl]-2-(2,3-difluorophenyl)thiazole-4-carboxamide

反応式

[F:1][C@H:2]1[C@H:8]([NH:9]C(=O)OC(C)(C)C)[CH2:7][CH2:6][C@@H:5]([C:17]2[N:18]([CH3:25])[N:19]=[CH:20][C:21]=2[N+:22]([O-])=O)[O:4][CH2:3]1.BrC1SC(NC(=O)OC(C)(C)C)=C(C(=O)NC2C=NN(C)C=2[C@@H]2CC[C@@H](NC(OC(C)(C)C)=O)[C@@H](F)CO2)N=1.C(OC([NH:72][C:73]1[S:77][C:76]([C:78]2[CH:83]=[CH:82][CH:81]=[C:80]([F:84])[C:79]=2[F:85])=[N:75][C:74]=1[C:86](O)=[O:87])=O)(C)(C)C>>[NH2:72][C:73]1[S:77][C:76]([C:78]2[CH:83]=[CH:82][CH:81]=[C:80]([F:84])[C:79]=2[F:85])=[N:75][C:74]=1[C:86]([NH:22][C:21]1[CH:20]=[N:19][N:18]([CH3:25])[C:17]=1[C@@H:5]1[CH2:6][CH2:7][C@@H:8]([NH2:9])[C@@H:2]([F:1])[CH2:3][O:4]1)=[O:87]