Hydrochloric Acid → 2-Cyclobutylphenol
反応式
Cl.[CH:2]1([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[O:12]COC)[CH2:5][CH2:4][CH2:3]1.CCOC(C)=O>CO>[CH:2]1([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[OH:12])[CH2:3][CH2:4][CH2:5]1参加物
5
反応条件
- 温度
- 60 °C
実験手順
After concentrated hydrochloric acid (3.1 mL) was added to a solution of 1-cyclobutyl-2-(methoxymethoxy)benzene (1.43 g) in MeOH (29 mL) at room temperature, the mixture was stirred at 60° C. for 2 hours. After the reaction mixture was cooled to room temperature, a standard buffer solution of pH 6.86 was added thereto, and EtOAc was added. Extraction was performed on the mixture using EtOAc, and the extract was washed with saturated brine. The organic layer was dried over Na2SO4 and filtered, and the filtrate was concentrated under reduced pressure, whereby 2-cyclobutylphenol (1.1 g) was obtained as a colorless oil.
後処理
- temperatureAfter the reaction mixture was cooled to room temperature
- additiona standard buffer solution of pH 6.86 was added
- extractionExtraction
- washthe extract was washed with saturated brine
- dry with materialThe organic layer was dried over Na2SO4
- filtrationfiltered
- concentrationthe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-556b5063bf5544718de54f043c805c00
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09328118B2
反応ノート
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