Imipramine → CID 16052002

HRID 522499

反応式

HRID 522499 の反応式
[CH:1]1[CH:2]=[CH:3][C:4]2[C:5](=[CH:7][C:8]([C:27]([OH:29])=[O:28])=[C:9]([OH:26])[C:10]=2[CH2:11][C:12]2[C:21]([OH:22])=[C:20]([C:23]([OH:25])=[O:24])[CH:19]=[C:18]3[C:13]=2[CH:14]=[CH:15][CH:16]=[CH:17]3)[CH:6]=1.[CH3:30][N:31]([CH2:33][CH2:34][CH2:35][N:36]1[C:46]2[CH:47]=[CH:48][CH:49]=[CH:50][C:45]=2[CH2:44][CH2:43][C:42]2[CH:41]=[CH:40][CH:39]=[CH:38][C:37]1=2)[CH3:32]>C(OCC)(=O)C>[CH3:30][N:31]([CH2:33][CH2:34][CH2:35][N:36]1[C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][C:42]=2[CH2:43][CH2:44][C:45]2[CH:50]=[CH:49][CH:48]=[CH:47][C:46]1=2)[CH3:32].[CH:1]1[CH:2]=[CH:3][C:4]2[C:5](=[CH:7][C:8]([C:27]([OH:29])=[O:28])=[C:9]([OH:26])[C:10]=2[CH2:11][C:12]2[C:21]([OH:22])=[C:20]([C:23]([OH:25])=[O:24])[CH:19]=[C:18]3[C:13]=2[CH:14]=[CH:15][CH:16]=[CH:17]3)[CH:6]=1

参加物

4

反応物 2

HCID 3696ImipramineHCID 8546Pamoic Acid

生成物 1

HCID 16052002CID 16052002収率 130.8%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

実験手順

To a slurry of Pamoic acid (32.4 g) in ethyl acetate (500 mL) in a clean round bottomed flask, Imipramine (150 g) solution in ethyl acetate is added at such a rate that the temperature remains below 50° C. for 3-4 h. After complete addition, the reaction mixture is stirred at room temperature for about 12-14 h. The bright yellow slurry thus obtained is filtered and washed with ethyl acetate (200 mL) and dried to get Imipramine Pamoate (73 g, 92%) as bright yellow crystalline product.

後処理

  1. additionAfter complete addition
  2. customThe bright yellow slurry thus obtained
  3. filtrationis filtered
  4. washwashed with ethyl acetate (200 mL)
  5. customdried

出典と根拠

ORDレコード
ord-4a65c4596e164399a2862199fd4b3204
出典データセット
uspto-grants-2016_05
特許番号
US09334240B2

関連ノート

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