化工社化工社 化学情報印刷レポート · 研究参考用
Dronedarone → 2-Butylbenzofuran-5-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dronedarone | HCID 208898 | — |
| 反応物 | 2-Butyl-5-nitrobenzofuran | HCID 9837358 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Platinum oxide (PtO) | HCID 82844 | — |
| 生成物 | 2-Butylbenzofuran-5-amine | HCID 9813311 | — |
反応手順
A process for synthesizing dronedarone was described in patent application WO 02/48132, mentioned previously, using 2-n-butyl-5-nitrobenzofuran, which is reduced, under pressure with hydrogen in the presence of platinum oxide as catalyst to form 2-n-butyl-5-aminobenzofuran. This benzofuran derivative is then subjected to the action of methanesulfonyl chloride, which gives 2-n-butyl-5-methanesulfonamidobenzofuran, which is treated with 4-[3-(di-n-butylamino)propoxy]benzoyl chloride to obtain dronedarone.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09334254B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-2f212b1e98fe444a8d6dbe3c7b91b1ad |
| 出典メモ | uspto-grants-2016_05 |