Benzenesulfonyl chloride → 5-Bromo-2-butylbenzofuran

HRID 522538ノート

反応式

HRID 522538 の反応式
C1(S(Cl)(=O)=O)C=CC=CC=1.C(N(CC)CC)C.[Br:18][C:19]1[CH:33]=[CH:32][C:22]([O:23][CH:24]([CH2:28][CH2:29][CH2:30][CH3:31])[C:25](O)=O)=[C:21](C=O)[CH:20]=1.CC1CCCCC1.C(OCC)(=O)C>C1(C)C=CC=CC=1>[CH2:28]([C:24]1[O:23][C:22]2[CH:21]=[CH:20][C:19]([Br:18])=[CH:33][C:32]=2[CH:25]=1)[CH2:29][CH2:30][CH3:31]

参加物

6

反応物 4

HCID 7369Benzenesulfonyl chlorideHCID 8471TriethylamineHCID 220578262-(4-Bromo-2-formylphenoxy)hexanoic acid3 回HCID 66985183Ethyl acetate methylcyclohexane

生成物 1

HCID 569260235-Bromo-2-butylbenzofuran

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

反応条件

温度
80 °C

実験手順

25.8 ml of benzenesulfonyl chloride (0.202 mol; 1.4 equivalents) and 40 ml of toluene are placed in an equipped reactor and the mixture is stirred at 80° C. 65 ml of anhydrous triethylamine (0.47 mol) and then 45.2 g of 2-(4-bromo-2-formylphenoxy)hexanoic acid (compound VIII) (0.144 mol) dissolved in 250 ml of toluene are then added slowly at 80° C. The reaction progress is monitored by TLC (eluent: 80/20 methylcyclohexane/ethyl acetate; Rf of compound VIII=0.08; Rf of the desired compound IX=0.80).

後処理

  1. additionare then added slowly at 80° C

出典と根拠

ORDレコード
ord-aaf4388929724f84b3113c0b1d7d133a
出典データセット
uspto-grants-2016_05
特許番号
US09334254B2

反応ノート

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