1,4-Dioxane hydrochloride → (1-(5-benzylpyrimidin-2-yl)piperazin-2-yl)methanol HCl salt
反応式
[CH2:1]([C:8]1[CH:9]=[N:10][C:11]([N:14]2[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH:15]2[CH2:27][OH:28])=[N:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:29].O1CCOCC1>>[ClH:29].[CH2:1]([C:8]1[CH:9]=[N:10][C:11]([N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH:15]2[CH2:27][OH:28])=[N:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
3
実験手順
A solution of tert-butyl 4-(5-benzylpyrimidin-2-yl)-3-(hydroxymethyl)piperazine-1-carboxylate (400 mg, 1.042 mmol) in 4 M HCl/dioxane (20 mL) was stirred at room temperature for 2 h. The reaction mixture was concentrated under reduced pressure to afford (1-(5-benzylpyrimidin-2-yl)piperazin-2-yl)methanol HCl salt (294 mg, 100%). MS (ES+) C16H20N4O requires: 284, found: 285 [M+H]+.
後処理
- concentrationThe reaction mixture was concentrated under reduced pressure