関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Propyl isocyanate | HCID 61033 | — |
| 反応物 | 2-(1-Naphthyl)-2-(methoxycarbonyl)ethylamine hydrochloride | HCID 19963460 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | N-[2-(1-naphthyl)-2-(methoxycarbonyl)ethyl]-N'-propylurea | HCID 19963469 | — |
反応手順
0.011 mol of propyl isocyanate is added dropwise and with magnetic stirring to a suspension of 0.01 mol of 2-(1-naphthyl)-2-(methoxycarbonyl)ethylamine hydrochloride, obtained in stage B of Example 11, in 5 cm3 of pyridine. The reaction medium is stirred for 1 hour at a temperature of 80° C. and then poured into ice-cold water. The mixture is acidified with 1N hydrochloric acid solution. The precipitate formed is drained, washed with water, dried and then recrystallized in a toluene/cyclohexane mixture.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05616614 |
|---|
| 出典データセット | uspto-grants-1997_04 |
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| ORD ID | ord-81fff63a0a274149931e6539d3a21426 |
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| 出典メモ | uspto-grants-1997_04 |
|---|
