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Maleic Anhydride → 4-(Trifluoromethyl)benzohydrazide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Maleic Anhydride | HCID 7923 | — |
| 反応物 | Hydrazine | HCID 9321 | — |
| 反応物 | Cycloheptatriene | HCID 11000 | — |
| 反応物 | Methyl 4-(trifluoromethyl)benzoate | HCID 520447 | — |
| 反応物 | Tecovirimat monohydrate | HCID 90479083 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 溶媒 | Toluene heptane | HCID 22263336 | — |
| 生成物 | 4-(Trifluoromethyl)benzohydrazide | HCID 520662 | — |
反応手順
More specifically, to prepare ST-246 monohydrate, Form I, cycloheptatriene is reacted with maleic anhydride in the presence of toluene to yield the major product, endo isomer. The exo isomer is further produced from about 7% to 0.6% by crystallization from toluene/heptane. Further, hydrazine in the anhydrous or hydrate form is reacted with Methyl 4-(trifluoromethyl)benzoate in the presence of isopropanol to yield (4-(trifluoromethyl)-benzhydrazide. The product is then crystallized from isopropanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09339466B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-5de744a66bb9456fb5708ea16b86e461 |
| 出典メモ | uspto-grants-2016_05 |